Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2824
2021
Details
- Autor(en) / Beteiligte
- Titel
- Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
- Ist Teil von
- Molecules (Basel, Switzerland), 2021-05, Vol.26 (9), p.2824
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that consists of Crohn’s disease (CD) and ulcerative colitis (UC). Cytokines are thought to be key mediators of inflammation-mediated pathological processes of IBD. These cytokines play a crucial role through the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways. Several small molecules inhibiting JAK have been used in clinical trials, and one of them has been approved for IBD treatment. Many anti-inflammatory phytochemicals have been shown to have potential as new drugs for IBD treatment. This review describes the significance of the JAK–STAT pathway as a current therapeutic target for IBD and discusses the recent findings that phytochemicals can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease models. Thus, we suggest that phytochemicals modulating JAK–STAT pathways are potential candidates for developing new therapeutic drugs, alternative medicines, and nutraceutical agents for the treatment of IBD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules26092824Titel-ID: cdi_doaj_primary_oai_doaj_org_article_58ab9b6042914f86bc3c3755afdc6e81
- Format
- –
- Schlagworte
- Animal diseases, Animal models, Binding sites, Cell division, Clinical trials, Crohn's disease, Cytokines, Drug development, Drugs, Functional foods & nutraceuticals, Gastrointestinal system, Gastrointestinal tract, Health services, Inflammation, Inflammatory bowel disease, inflammatory bowel disease (IBD), Inflammatory bowel diseases, Intestine, Janus kinase, janus kinase (JAK), Kinases, Pathogenesis, Phosphorylation, Phytochemicals, Proteins, Review, Rheumatoid arthritis, signal transducer and activator of transcription (STAT), Signs and symptoms, Therapeutic targets, Transcription, Tumor necrosis factor-TNF, Ulcerative colitis