Details

Autor(en) / Beteiligte

• Prigitano, Anna
• Blasi, Elisabetta
• Calabrò, Maria
• Cavanna, Caterina
• Cornetta, Maria
• Farina, Claudio
• Grancini, Anna
• Innocenti, Patrizia
• Lo Cascio, Giuliana
• Nicola, Lucia
• Trovato, Laura
• Cogliati, Massimo
• Esposto, Maria Carmela
• Tortorano, Anna Maria
• Romanò, Luisa
• On Behalf Of The FiCoV Study Group

Titel

Yeast Bloodstream Infections in the COVID-19 Patient: A Multicenter Italian Study (FiCoV Study)

Ist Teil von

• Journal of fungi (Basel), 2023-02, Vol.9 (2), p.277

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Fungemia is a co-infection contributing to the worsening of the critically ill COVID-19 patient. The multicenter Italian observational study FiCoV aims to estimate the frequency of yeast bloodstream infections (BSIs), to describe the factors associated with yeast BSIs in COVID-19 patients hospitalized in 10 hospitals, and to analyze the antifungal susceptibility profiles of the yeasts isolated from blood cultures. The study included all hospitalized adult COVID-19 patients with a yeast BSI; anonymous data was collected from each patient and data about antifungal susceptibility was collected. Yeast BSI occurred in 1.06% of patients, from 0.14% to 3.39% among the 10 participating centers. Patients were mainly admitted to intensive or sub-intensive care units (68.6%), over 60 years of age (73%), with a mean and median time from the hospitalization to fungemia of 29 and 22 days, respectively. Regarding risk factors for fungemia, most patients received corticosteroid therapy during hospitalization (61.8%) and had a comorbidity (25.3% diabetes, 11.5% chronic respiratory disorder, 9.5% cancer, 6% haematological malignancies, 1.4% organ transplantation). Antifungal therapy was administered to 75.6% of patients, mostly echinocandins (64.5%). The fatality rate observed in COVID-19 patients with yeast BSI was significantly higher than that of COVID-19 patients without yeast BSI (45.5% versus 30.5%). (49.8%) and (35.2%) were the most fungal species isolated; 72% of strains were fluconazole-resistant (range 0-93.2% among the centers). The FiCoV study highlights a high prevalence of BSIs in critically ill COVID-19 patients, especially hospitalized in an intensive care unit, a high fatality rate associated with the fungal co-infection, and the worrying spread of azole-resistant