Details

Autor(en) / Beteiligte

• Yu, Bolan
• Bai, Chuan
• He, Xixin
• Huang, Zhaofeng
• Tian, Xuyan
• Yin, Meng
• Liang, Jinhao
• Su, Qiao
• Zhao, Qingyu
• Wei, Fengjiao
• Chen, Huanpeng
• Zhou, Xiaoqing
• Liu, Zhonghua
• Rigopoulou, Eirini
• Eirini Rigopoulou

Titel

3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation

Ist Teil von

• Journal of immunology research, 2019, Vol.2019 (2019), p.1-10

Ort / Verlag

Cairo, Egypt: Hindawi Publishing Corporation

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Th17 activity has been implicated in systemic lupus erythematosus (SLE), which is a systemic autoimmune disease with a typical clinical manifestation of lupus nephritis (LN). Retinoic acid receptor-related orphan receptor gamma t (RORγt) has been shown to be important for Th17 differentiation. In this study, we evaluated the inhibition of RORγt activity by 3β-acetyloxy-oleanolic acid (AOA), a small molecule isolated from the root of Symplocos laurina, a traditional herb belonging to South China. We demonstrated that AOA can inhibit RORγt activity and prevent SLE pathogenesis in a pristane-induced LN model. The results showed that AOA decreased RORγt transcription activity in a reporter assay and prevented Th17 differentiation in vitro. In vivo studies showed that AOA treatment decreased serum anti-dsDNA antibody and alleviated renal pathologic damage as well as antibody complex accumulation in the pristane-induced LN model. These results demonstrated that AOA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.