Details

Autor(en) / Beteiligte

• Wang, Wei
• Ma, Yucheng
• Chen, Jiawei
• Peng, Liao
• Gao, Xiaoshuai
• Lin, Lede
• Zhang, Fuxun
• Xiong, Yang
• Qin, Feng
• Yuan, Jiuhong

Titel

The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction

Ist Teil von

• Frontiers in public health, 2022-06, Vol.10, p.910251-910251

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background 2, 4-dichlorophenoxyacetic acid (2,4-D) is one of the most frequently used herbicides in the world, and it has been linked with low testosterone; however, studies regarding its effect on erectile function are limited. The current study aimed to determine the association between the 2,4-D exposure and erectile dysfunction (ED) in men from the National Health and Nutrition Examination Survey (NHANES). Methods We analyzed data for urinary 2,4-D levels from 1,311 men (>20 years of age) in the NHANES 2001–2004. ED was assessed by a single, validated survey question. Multivariable logistic regression analysis utilizing sampling weights was performed to determine the relationship between 2,4-D exposure and ED. Results Multivariable logistic regression models demonstrated no statistically significant association between 2,4-D exposure and ED after full adjustment [odds ratio (OR) 1.02; 95% CI 0.77–1.36; P = 0.882)]. Men in the 2,4-D quartile 4 groups were not associated with an increased risk of ED (OR 1.13; 95% CI 0.74–1.75; P for trend = 0.481). Furthermore, the association between urinary 2,4-D level and ED was not significant in the subgroup analysis stratified by age, BMI, cardiovascular disease, hypertension, diabetes, and high cholesterol. Conclusion We demonstrated that there was no association between 2,4-D exposure and ED. Further studies are warranted to corroborate our results.