Details

Autor(en) / Beteiligte

• Zhou, He-Ming
• Zhang, Ji-Gang
• Zhang, Xue
• Li, Qin

Titel

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

Ist Teil von

• Signal transduction and targeted therapy, 2021-02, Vol.6 (1), p.62-17, Article 62

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient outcomes and reduce relapse by altering therapeutic regimens. Here, we reviewed the identification of CSCs, the intrinsic and extrinsic mechanisms of therapy resistance in CSCs, the signaling pathways of CSCs that mediate treatment failure, and potential CSC-targeting agents in various tumors from the clinical perspective. Targeting the mechanisms and pathways described here might contribute to further drug discovery and therapy.