Molecules (Basel, Switzerland), 2023-08, Vol.28 (16), p.5956
2023
Details
- Autor(en) / Beteiligte
- Titel
- A Chiral Relay Race: Stereoselective Synthesis of Axially Chiral Biaryl Diketones through Ring-Opening of Optical Dihydrophenan-threne-9,10-diols
- Ist Teil von
- Molecules (Basel, Switzerland), 2023-08, Vol.28 (16), p.5956
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2023
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- We report herein a point-to-axial chirality transfer reaction of optical dihydrophenanthrene-9,10-diols for the synthesis of axially chiral diketones. Two sets of conditions, namely a basic tBuOK/air atmosphere and an acidic NaClO/n-Bu4NHSO4, were developed to oxidatively cleave the C-C bond, resulting in the formation of axially chiral biaryl diketones. Finally, brief synthetic applications of the obtained chiral aryl diketones were demonstrated.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules28165956Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5684c6f0715d4de8b0e2730d13636a23
- Format
- –
- Schlagworte
- axially chiral diketone, C-C bond cleavage, Carbon, Catalysis, chiral relay race, Chromatography, diol, Glycols, Ketones, Nitrogen, Oxidation, Potassium, Single crystals, Stereoisomers