Details

Autor(en) / Beteiligte

• Yang, Yong-Dong
• Yu, Xing
• Wang, Xiu-Mei
• Mu, Xiao-Hong
• He, Feng

Titel

Tanshinone ⅡA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

Ist Teil von

• Neural regeneration research, 2017-02, Vol.12 (2), p.267-275

Ort / Verlag

India: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Tanshinone ⅡA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone ⅡA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone ⅡA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion（L6–S1） cells was less after treatment with tanshinone ⅡA. The effects of tanshinone ⅡA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone ⅡA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.