Details

Autor(en) / Beteiligte

• Chen, Defu
• Zheng, Huifen
• Huang, Zhiyong
• Lin, Huiyun
• Ke, Zhidong
• Xie, Shusen
• Li, Buhong
• Liu, Timon Cheng-Yi

Titel

Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy

Ist Teil von

• International journal of photoenergy, 2012-01, Vol.2012, p.1-6

Ort / Verlag

New York: Hindawi Publishing Corporation

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70 LEDs centered at 643 nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.