Details

Autor(en) / Beteiligte

• Pardi, Norbert
• Parkhouse, Kaela
• Kirkpatrick, Ericka
• McMahon, Meagan
• Zost, Seth J
• Mui, Barbara L
• Tam, Ying K
• Karikó, Katalin
• Barbosa, Christopher J
• Madden, Thomas D
• Hope, Michael J
• Krammer, Florian
• Hensley, Scott E
• Weissman, Drew

Titel

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Ist Teil von

• Nature communications, 2018-08, Vol.9 (1), p.3361-12, Article 3361

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. Here, we evaluate a potent broadly protective influenza virus vaccine candidate that uses nucleoside-modified and purified mRNA encoding full-length influenza virus HA formulated in lipid nanoparticles (LNPs). We demonstrate that immunization with HA mRNA-LNPs induces antibody responses against the HA stalk domain of influenza virus in mice, rabbits, and ferrets. The HA stalk-specific antibody response is associated with protection from homologous, heterologous, and heterosubtypic influenza virus infection in mice.