Orphanet journal of rare diseases, 2020-05, Vol.15 (1), p.126-126, Article 126
- Opladen, Thomas
- López-Laso, Eduardo
- Cortès-Saladelafont, Elisenda
- Pearson, Toni S
- Sivri, H Serap
- Yildiz, Yilmaz
- Assmann, Birgit
- Kurian, Manju A
- Leuzzi, Vincenzo
- Heales, Simon
- Pope, Simon
- Porta, Francesco
- García-Cazorla, Angeles
- Honzík, Tomáš
- Pons, Roser
- Regal, Luc
- Goez, Helly
- Artuch, Rafael
- Hoffmann, Georg F
- Horvath, Gabriella
- Thöny, Beat
- Scholl-Bürgi, Sabine
- Burlina, Alberto
- Verbeek, Marcel M
- Mastrangelo, Mario
- Friedman, Jennifer
- Wassenberg, Tessa
- Jeltsch, Kathrin
- Kulhánek, Jan
- Kuseyri Hübschmann, Oya
2020
Details
- Autor(en) / Beteiligte
- Opladen, Thomas
- López-Laso, Eduardo
- Cortès-Saladelafont, Elisenda
- Pearson, Toni S
- Sivri, H Serap
- Yildiz, Yilmaz
- Assmann, Birgit
- Kurian, Manju A
- Leuzzi, Vincenzo
- Heales, Simon
- Pope, Simon
- Porta, Francesco
- García-Cazorla, Angeles
- Honzík, Tomáš
- Pons, Roser
- Regal, Luc
- Goez, Helly
- Artuch, Rafael
- Hoffmann, Georg F
- Horvath, Gabriella
- Thöny, Beat
- Scholl-Bürgi, Sabine
- Burlina, Alberto
- Verbeek, Marcel M
- Mastrangelo, Mario
- Friedman, Jennifer
- Wassenberg, Tessa
- Jeltsch, Kathrin
- Kulhánek, Jan
- Kuseyri Hübschmann, Oya
- Titel
- Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH 4 ) deficiencies
- Ist Teil von
- Orphanet journal of rare diseases, 2020-05, Vol.15 (1), p.126-126, Article 126
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tetrahydrobiopterin (BH ) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH biosynthesis or recycling. Hyperphenylalaninemia (HPA) is the first diagnostic hallmark for most BH deficiencies, apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency and sepiapterin reductase deficiency. Early supplementation of neurotransmitter precursors and where appropriate, treatment of HPA results in significant improvement of motor and cognitive function. Management approaches differ across the world and therefore these guidelines have been developed aiming to harmonize and optimize patient care. Representatives of the International Working Group on Neurotransmitter related Disorders (iNTD) developed the guidelines according to the SIGN (Scottish Intercollegiate Guidelines Network) methodology by evaluating all available evidence for the diagnosis and treatment of BH deficiencies. Although the total body of evidence in the literature was mainly rated as low or very low, these consensus guidelines will help to harmonize clinical practice and to standardize and improve care for BH deficient patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1750-1172eISSN: 1750-1172DOI: 10.1186/s13023-020-01379-8Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5335fbb4b17444b0bc5403d7a034e417
- Format
- –
- Schlagworte
- 6-pyruvoyltetrahydropterin synthase deficiency, BH4, Biopterins - analogs & derivatives, Biopterins - therapeutic use, Biosynthesis, Brain research, Cognitive ability, Diagnosis, Dopamine, Dystonia, Enzymes, Guanosine, Guanosine triphosphate cyclohydrolase deficiency, Guanosine triphosphate cyclohydrolase I, Humans, Laboratories, Medical diagnosis, Medical screening, Meetings, Metabolic disorders, Metabolism, Metabolism, Inborn Errors, Mutation, Neurotransmitter, Neurotransmitters, Patients, Phenylketonurias - diagnosis, Phenylketonurias - drug therapy, Phenylketonurias - genetics, Review, Sepiapterin reductase, Sepiapterin reductase deficiency, pterin-4-alpha-carbinolamine dehydratase deficiency, Serotonin, Supplementation, Tetrahydrobiopterin, Tetrahydrobiopterin deficiency, Working groups