Details

Autor(en) / Beteiligte

• Getahun Strobel, Aneley
• Prasad, Prinika
• Prasad, Vinita
• Naidu, Ravi
• Young-Sharma, Tracey
• Suka, Ana
• Richards, Matthew
• Cameron, Donna
• Lane, Courtney R.
• Buising, Kirsty
• Howden, Benjamin P.
• Autar, Sanjeshni

Titel

The epidemiology of enterococci in a tertiary hospital and primary healthcare facilities in Fiji (2019–2022)

Ist Teil von

• Journal of global antimicrobial resistance., 2024-06, Vol.37, p.102-107

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •The majority of enterococcal isolates were not routinely characterised to the species level.•Vancomycin resistance was 4.8% amongst all enterococcal isolates combined. In the Colonial War Memorial Hospital vancomycin resistance among the subset identified to the species level was 17.2% in E. faecium and 2.4% in E. faecalis isolates.•All tested vancomycin resistance enterococci isolates expressed vanA gene.•Enhanced phenotypic and molecular surveillance are needed to better understand enterococci epidemiology in Fiji. We analysed 4 y of laboratory data to characterise the species and determine the antimicrobial susceptibility profiles of enterococci as human pathogens in Fiji. The study also investigated the molecular epidemiology amongst the subset of vancomycin-resistant enterococci (VRE). This retrospective study reviewed bacteriological data from Colonial War Memorial Hospital (CWMH) and other healthcare facilities in the Central and Eastern divisions of Fiji. Phenotypic, antimicrobial susceptibility and vanA and vanB PCR testing were performed using locally approved protocols. The first clinical isolates per patient with antimicrobial susceptibility testing results in a single year were included in the analysis. Data was analysed using WHONET software and Microsoft Excel. A total of 1817 enterococcal isolates were reported, 1415 from CWMH and 402 from other healthcare facilities. The majority of isolates, 75% (n = 1362) were reported as undifferentiated Enterococcus spp., 17.8% (n = 324) were specifically identified as Enterococcus faecalis and 6.7% (n = 122) as E. faecium. Overall, 10% of the enterococci isolates were from blood cultures. Among isolates from CWMH, <15% of E. faecium were susceptible to ampicillin, and 17.2% were vancomycin resistant. Overall, 874 enterococcal isolates (including the undifferentiated species) were tested against vancomycin, of which 4.8% (n = 42) were resistance. All of the VRE isolates tested (n = 15) expressed vanA genes. This study demonstrates the clinical importance of VRE, particularly van A E. faecium in the national referral hospital in Fiji. Enhanced phenotypic and molecular surveillance data are needed to better understand enterococci epidemiology and help guide specific infection prevention and control measures and antibiotic prescribing guidelines.