Details

Autor(en) / Beteiligte

• Bodin, Justine
• Adrien, Amandine
• Bodet, Pierre-Edouard
• Dufour, Delphine
• Baudouin, Stanislas
• Maugard, Thierry
• Bridiau, Nicolas

Titel

Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts

Ist Teil von

• Molecules (Basel, Switzerland), 2020-04, Vol.25 (9), p.2091

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• With the increase in life expectancy, reducing the visible signs of skin aging has become a major issue. A reduction in collagen and hyaluronic acid synthesis by fibroblasts is a feature of skin aging. The green seaweed, , is an abundant and rich source of nutrients, especially proteins and peptides. The aim of this study was to assess the potential cosmetic properties of a protein fraction from (PROT-1) containing 51% of proteins and 22% of polysaccharides, and its enzymatic peptide hydrolysates on human dermal fibroblasts. PROT-1 was extracted using a patented acid- and solvent-free process (FR2998894 (B1)). The biochemical characterization and chromatographic analysis showed a main set of proteins (25 kDa). To demonstrate the anti-aging potential of PROT-1, fibroblast proliferation and collagen and hyaluronic acid production were assessed on fibroblast cell lines from donors aged 20 years (CCD-1059Sk) and 46 years (CCD-1090Sk). PROT-1 induced a significant increase in collagen and hyaluronic acid production per cell, and a reduction in cell proliferation without increasing cell mortality. These effects were reversed after protein hydrolysis of PROT-1, showing the central role of proteins in this promising anti-aging property.