Details

Autor(en) / Beteiligte

• Zhang, Meng-ling
• Yang, Qian
• Li, Xiao-peng
• Chen, Jia-hao
• Bi, Zi-jun
• Shan, Yang
• Gao, Li-fang
• Yu, Huan-ling

Titel

Nobiletin inhibits hypoxia-induced placental redox imbalance and subsequent offspring brain damage by regulating the one-carbon metabolism

Ist Teil von

• Journal of functional foods, 2023-11, Vol.110, p.105870, Article 105870

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• [Display omitted] •Nobiletin inhibits hypoxia-induced placental redox imbalance.•Nobiletin inhibits offspring brain damage caused by placental hypoxia.•One carbon metabolism is crucial for inhibiting placental redox imbalance. Nobiletin (NOB) is one of the major polymethoxyflavone in citrus peels, which has antioxidant activities. The purpose of this study was to investigate the effects of NOB on hypoxia-induced placental oxidative stress and its mechanism. In vitro experiments, JEG-3 hypoxic model was constructed, and treated with 100 μM NOB. In vivo experiment, pregnant rats were injected intraperitoneally with 50 mg/kg body weight NOB daily, and the placental hypoxia model was established by RUPP. NOB hampered the reducing of reducing power in hypoxic cells, promoted NADPH to provide hydrogen donors to regenerate antioxidants GPX and GSH, thereby promoting the decomposition of ROS. NOB alleviated the adverse reaction of hypoxic placental one-carbon metabolism disorder by regulating the levels of homocysteine, DNMTs and TETs. Moreover, NOB suppressed offspring brain damage induced by RUPP. Taken together, NOB attenuated hypoxia-induced placental redox perturbation and subsequent offspring brain injury by modulating one-carbon metabolism.