Details

Autor(en) / Beteiligte

• Benyamin, Beben
• He, Ji
• Zhao, Qiongyi
• Gratten, Jacob
• Garton, Fleur
• Leo, Paul J
• Liu, Zhijun
• Mangelsdorf, Marie
• Al-Chalabi, Ammar
• Anderson, Lisa
• Butler, Timothy J
• Chen, Lu
• Chen, Xiang-Ding
• Cremin, Katie
• Deng, Hong-Weng
• Devine, Matthew
• Edson, Janette
• Fifita, Jennifer A
• Furlong, Sarah
• Han, Ying-Ying
• Harris, Jessica
• Henders, Anjali K
• Jeffree, Rosalind L
• Jin, Zi-Bing
• Li, Zhongshan
• Li, Ting
• Li, Mengmeng
• Lin, Yong
• Liu, Xiaolu
• Marshall, Mhairi
• McCann, Emily P
• Mowry, Bryan J
• Ngo, Shyuan T
• Pamphlett, Roger
• Ran, Shu
• Reutens, David C
• Rowe, Dominic B
• Sachdev, Perminder
• Shah, Sonia
• Song, Sharon
• Tan, Li-Jun
• Tang, Lu
• van den Berg, Leonard H
• van Rheenen, Wouter
• Veldink, Jan H
• Wallace, Robyn H
• Wheeler, Lawrie
• Williams, Kelly L
• Wu, Jinyu
• Wu, Xin
• Yang, Jian
• Yue, Weihua
• Zhang, Zong-Hong
• Zhang, Dai
• Noakes, Peter G
• Blair, Ian P
• Henderson, Robert D
• McCombe, Pamela A
• Visscher, Peter M
• Xu, Huji
• Bartlett, Perry F
• Brown, Matthew A
• Wray, Naomi R
• Fan, Dongsheng

Titel

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

Ist Teil von

• Nature communications, 2017-09, Vol.8 (1), p.611-7, Article 611

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls. We find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1.3 × 10 ), with replication support from two independent Australian samples (combined 576 cases and 683 controls, p = 1.7 × 10 ). Both GPX3 and TNIP1 interact with other known ALS genes (SOD1 and OPTN, respectively). In addition, GGNBP2 was identified using gene-based analysis and summary statistics-based Mendelian randomization analysis, although further replication is needed to confirm this result. Our results increase our understanding of genetic aetiology of ALS.Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease. Here, Wray and colleagues identify association of the GPX3-TNIP1 locus with ALS using cross-ethnic meta-analyses.