Details

Autor(en) / Beteiligte

• Wang, Jing
• Liu, Jianjun
• Pan, Huayuan
• Jiang, Chenghao
• Liu, Song
• Zhu, Zhengzhi
• Fang, Jing
• Zheng, Xucai
• Hong, Shikai
• Wang, Shengying

Titel

Young age increases the risk of lymph node positivity in papillary thyroid cancer patients: a SEER data-based study

Ist Teil von

• Cancer management and research, 2018-01, Vol.10, p.3867-3873

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Currently in papillary thyroid cancer (PTC), the correlation between lymph node positivity (LN+) and patient's age at diagnosis is still inconclusive. The aim of this study was to investigate whether younger PTC patients had higher LN+ rates. From the 1998-2013 Surveillance, Epidemiology, and End Results database, we analyzed PTC patients with at least 1 LN examined. The patients were divided into 5 groups by age separately for each T stage: ≤30; 31-40; 41-50; 51-60; >60 years. A total of 46,077 PTC patients were identified, including 8,386 (18.2%) patients aged ≤30 years, 10,971 (23.8%) patients aged 31-40 years, 11,646 (25.3%) patients aged 41-50 years, 8,596 (18.7%) patients aged 51-60 years, and 6,478 (14.1%) patients aged >60 years. In each T stage, LN+ rates were inversely associated with age at diagnosis, which was validated by multivariate logistic regression analysis ( <0.001). In addition, the subset of patients 30 or younger had the highest lymph node ratio compared with other subsets ( <0.001). We identified that younger PTC patients have an increased predisposition for LN+ regardless of T stage. This finding could help surgeons to select the optimal treatment for younger PTC patients.