Cancers, 2019-02, Vol.11 (2), p.231
2019
Details
- Autor(en) / Beteiligte
- Titel
- Nitric Oxide Antagonism to Anti-Glioblastoma Photodynamic Therapy: Mitigation by Inhibitors of Nitric Oxide Generation
- Ist Teil von
- Cancers, 2019-02, Vol.11 (2), p.231
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- Many studies have shown that low flux nitric oxide (NO) produced by inducible NO synthase (iNOS/NOS2) in various tumors, including glioblastomas, can promote angiogenesis, cell proliferation, and migration/invasion. Minimally invasive, site-specific photodynamic therapy (PDT) is a highly promising anti-glioblastoma modality. Recent research in the authors' laboratory has revealed that iNOS-derived NO in glioblastoma cells elicits resistance to 5-aminolevulinic acid (ALA)-based PDT, and moreover endows PDT-surviving cells with greater proliferation and migration/invasion aggressiveness. In this contribution, we discuss iNOS/NO antagonism to glioblastoma PDT and how this can be overcome by judicious use of pharmacologic inhibitors of iNOS activity or transcription.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6694eISSN: 2072-6694DOI: 10.3390/cancers11020231Titel-ID: cdi_doaj_primary_oai_doaj_org_article_502423e3f2e7434882e2558a4177848e
- Format
- –
- Schlagworte
- Aminolevulinic acid, Angiogenesis, Apoptosis, Brain cancer, Cancer therapies, Cell migration, Cell proliferation, Chemotherapy, Cytotoxicity, DNA damage, Enzymes, FDA approval, Glioblastoma, Glioblastoma cells, glioblastoma PDT, inducible nitric oxide synthase (iNOS), Light, Medical prognosis, Nitric oxide, nitric oxide (NO), Nitric-oxide synthase, NO-mediated PDT resistance, Photodynamic therapy, photodynamic therapy (PDT), Prostate, Radiation therapy, Review, Transcription, Tumors