Details

Autor(en) / Beteiligte

• Smith, Ezra E.
• Schüller, Thomas
• Huys, Daniel
• Baldermann, Juan Carlos
• Andrade, Pablo
• Allen, John JB
• Visser-Vandewalle, Veerle
• Ullsperger, Markus
• Gruendler, Theo O.J.
• Kuhn, Jens

Titel

A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes

Ist Teil von

• NeuroImage (Orlando, Fla.), 2020-10, Vol.220, p.117138-117138, Article 117138

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Closed-loop neuromodulation is presumed to be the logical evolution for improving the effectiveness of deep brain stimulation (DBS) treatment protocols (Widge et al., 2018). Identifying symptom-relevant biomarkers that provide meaningful feedback to stimulator devices is an important initial step in this direction. This report demonstrates a technique for assaying neural circuitry hypothesized to contribute to OCD and DBS treatment outcomes. We computed phase-lag connectivity between LFPs and EEGs in thirteen treatment-refractory OCD patients. Simultaneous recordings from scalp EEG and externalized DBS electrodes in the ventral capsule/ventral striatum (VC/VS) were collected at rest during the perioperative treatment stage. Connectivity strength between midfrontal EEG sensors and VC/VS electrodes correlated with baseline OCD symptoms and 12-month posttreatment OCD symptoms. Results are qualified by a relatively small sample size, and limitations regarding the conclusiveness of VS and mPFC as neural generators given some concerns about volume conduction. Nonetheless, findings are consistent with treatment-relevant tractography findings and theories that link frontostriatal hyperconnectivity to the etiopathogenesis of OCD. Findings support the continued investigation of connectivity-based assays for aiding in determination of optimal stimulation location, and are an initial step towards the identification of biomarkers that can guide closed-loop neuromodulation systems. •Phase-lag connectivity may inform closed-loop neuromodulation.•Change in frontostriatal (hyper)connectivity may be a therapeutic mechanism of DBS.•Phase-lag connectivity between frontal and striatal regions predicts OCD severity.•Network-level metrics may be useful for guiding on-demand neuromodulation.•Findings support frontostriatal theories of OCD etiopathogenesis.