Details

Autor(en) / Beteiligte

• Breslin, Thomas
• Paino, Jason
• Wegner, Marie
• Engels, Elette
• Fiedler, Stefan
• Forrester, Helen
• Rennau, Hannes
• Bustillo, John
• Cameron, Matthew
• Häusermann, Daniel
• Hall, Christopher
• Krause, Dieter
• Hildebrandt, Guido
• Lerch, Michael
• Schültke, Elisabeth

Titel

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

Ist Teil von

• Biomimetics (Basel, Switzerland), 2023-05, Vol.8 (2), p.230

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.