Details

Autor(en) / Beteiligte

• Huang, Can-Yu
• Ye, Zi-Han
• Huang, Mu-Yang
• Lu, Jin-Jian

Titel

Regulation of CD47 expression in cancer cells

Ist Teil von

• Translational oncology, 2020-12, Vol.13 (12), p.100862-100862, Article 100862

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance. Targeting the phagocytosis checkpoint of CD47-SIRPα axis has shown remarkable anticancer effect in preclinical and clinical research, which indicates the potential application of CD47-SIRPα blockade for cancer treatment. In this case, the comprehensive description of the regulation of CD47 in different types of cancer cells has significant implications for furthering our understanding of the role of CD47 in cancer. Based on the current reports, we summarized the regulatory factors, i.e., cytokines, oncogenes, microRNAs as well as enzymes, of CD47 expression in cancer cells. Accordingly, we also proposed several points needing further research, hoping to provide useful insights for the future investigation on the regulation of CD47 in cancers. CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance. In this case, the comprehensive understandings of the regulation of CD47 in cancer cells are essential for further developments. In this review, based on the current reports, we summarized that CD47 expression could be regulated by cytokines, oncogenes, microRNAs and enzymes in cancer cells. Likewise, CD47 expression could be regulated at the transcriptional level, post-transcriptional level, post-translational modification level, etc. However, further studies are required to determine other factors that regulate CD47 expression. [Display omitted] •Cytokines, oncogenes, microRNAs and enzymes regulate CD47 expression in cancer.•CD47 expression could be regulated at the transcriptional, post-transcriptional and post-translational modification level.•Further studies are required to determine other factors that regulate CD47 expression.