Details

Autor(en) / Beteiligte

• Grintzalis, Konstantinos
• Patsoukis, Nikolaos
• Papapostolou, Ioannis
• Zervoudakis, George
• Kalaitzopoulou, Electra
• Georgiou, Christos D.
• Matsokis, Nikolaos A.
• Panagopoulos, Nikolaos T.

Titel

Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging

Ist Teil von

• Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe, 2022-12, Vol.6, p.100043, Article 100043

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Oxidative damage leads to the aging-related dysfunction in mouse brain.•Identification of oxidative stress (OS) markers of thiol redox status is crucial in relation to aging.•Protein reduced and oxidized thiols are introduced as OS aging markers. Aging is a natural process in organisms with its underlying mechanisms remaining unknown. Brain aging is accompanied by cognitive deficits and movement disorders, which signify the importance of elaborating its main mechanisms. In this study, oxidative stress biomarkers for lipid peroxidation and thiol redox state were assessed in different brain areas in male mice, categorised in respect to aging as young (three months), middle (eleven months) and elder aged (twenty-three months). Senescence was associated with an increase of lipid peroxidation and a decrease of reduced and oxidized glutathione. In some brain areas, reduced cysteine and oxidized protein thiols were increased with aging. Results support the theory that aging is associated with oxidative stress in the brain of mice and provide an insight in the biochemical aspect of aging in reference to thiol redox status as a potential marker for aging.