Details

Autor(en) / Beteiligte

• Woo, Hyun Jun
• Yang, Ji Yeong
• Lee, Min Ho
• Kim, Hyun Woo
• Kwon, Hye Jin
• Park, Min
• Kim, Sung-Kyu
• Park, So-Young
• Kim, Sa-Hyun
• Kim, Jong-Bae

Titel

Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo

Ist Teil von

• International journal of molecular sciences, 2020-02, Vol.21 (3), p.1008

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The human specific bacterial pathogen ( ) is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less effectively. Therefore, development of a new antimicrobial agent is required to control infection. In the current study, the inhibitory effect of β-caryophyllene on growth, as well as the antibacterial therapeutic effect, has been demonstrated. β-caryophyllene inhibited growth via the downregulation of E, N, B, and A and also downregulated virulence factors such as CagA, VacA, and SecA proteins. β-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into -infected AGS gastric cancer cells was decreased by β-caryophyllene treatment. β-caryophyllene also inhibited VacA entry through the downregulation of T5 SS. After β-caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic effects in the treated groups. Hematological data, which was consistent with histological data, support the therapeutic effect of β-caryophyllene administration. Such a positive effect of β-caryophyllene on infection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food to help patients who are suffering from gastroduodenal diseases due to infection.