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Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo
Ist Teil von
International journal of molecular sciences, 2020-02, Vol.21 (3), p.1008
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2020
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The human specific bacterial pathogen
(
) is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less effectively. Therefore, development of a new antimicrobial agent is required to control
infection. In the current study, the inhibitory effect of β-caryophyllene on
growth, as well as the antibacterial therapeutic effect, has been demonstrated. β-caryophyllene inhibited
growth via the downregulation of
E,
N,
B, and
A and also downregulated virulence factors such as CagA, VacA, and SecA proteins. β-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into
-infected AGS gastric cancer cells was decreased by β-caryophyllene treatment. β-caryophyllene also inhibited VacA entry through the downregulation of T5
SS. After β-caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic effects in the treated groups. Hematological data, which was consistent with histological data, support the therapeutic effect of β-caryophyllene administration. Such a positive effect of β-caryophyllene on
infection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food to help patients who are suffering from gastroduodenal diseases due to
infection.