Journal for Immunotherapy of Cancer, 2018-06, Vol.6 (1), p.56-56, Article 56
2018
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Cytokine release syndrome
- Ist Teil von
- Journal for Immunotherapy of Cancer, 2018-06, Vol.6 (1), p.56-56, Article 56
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2018
- Quelle
- EZB-FREE-00999 freely available EZB journals
- Beschreibungen/Notizen
- During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody constructs and chimeric antigen receptor (CAR) T cells have shown remarkable efficacy in clinical trials and some of these agents have already received regulatory approval. However, along with growing experience in the clinical application of these potent immunotherapeutic agents comes the increasing awareness of their inherent and potentially fatal adverse effects, most notably the cytokine release syndrome (CRS). This review provides a comprehensive overview of the mechanisms underlying CRS pathophysiology, risk factors, clinical presentation, differential diagnoses, and prognostic factors. In addition, based on the current evidence we give practical guidance to the management of the cytokine release syndrome.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2051-1426eISSN: 2051-1426DOI: 10.1186/s40425-018-0343-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_4e42cfc3a5554db7994294927b647d67
- Format
- –
- Schlagworte
- Antibodies, Cancer, Cancer therapies, CAR T cells, Care and treatment, Cytokine release syndrome, Cytokine storm, Cytokines, Drug dosages, Edema, FDA approval, Fever, Immunotherapy, Influenza, Laboratories, Leukemia, Lymphocytes, Lymphoma, Neurotoxicity, Review, Steroids, T cell-engaging therapies, T cells, Ventilators, Viral antibodies, Viral infections