Molecules (Basel, Switzerland), 2020-05, Vol.25 (9), p.2254
2020
Details
- Autor(en) / Beteiligte
- Titel
- Wide-Antimicrobial Spectrum of Picolinium Salts
- Ist Teil von
- Molecules (Basel, Switzerland), 2020-05, Vol.25 (9), p.2254
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C , C , C ) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C and C side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the -alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules25092254Titel-ID: cdi_doaj_primary_oai_doaj_org_article_4cd878c40b944f69ad4c9d84c9b6eb82
- Format
- –
- Schlagworte
- Animals, Anti-Bacterial Agents - pharmacology, Anti-Infective Agents - pharmacology, Antibiotic resistance, Antibiotics, Antiinfectives and antibacterials, Antimicrobial activity, Antimicrobial agents, Antiviral Agents - pharmacology, Aromatic compounds, Bacteria, Biological activity, Candida - drug effects, Cell Survival - drug effects, Chains, CHO Cells, Cricetulus, critical micellar concentration, Cytotoxicity, E coli, Fungi, Fungi - drug effects, Fungicides, Gram-Negative Bacteria - drug effects, Gram-Positive Bacteria - drug effects, Herpesvirus 3, Human - drug effects, Lipophilicity, Mammalian cells, Microbial Sensitivity Tests, Microorganisms, Morbidity, Nosocomial infection, Picolinic Acids - chemical synthesis, Picolinic Acids - chemistry, Picolinic Acids - pharmacology, picolinium salts, quaternary ammonium compounds, Quaternary Ammonium Compounds - chemistry, Quaternary Ammonium Compounds - pharmacology, Salts, Staphylococcus infections, Structure-Activity Relationship, Surface-Active Agents - chemistry, Surface-Active Agents - pharmacology, surfactant, Surfactants