Details

Autor(en) / Beteiligte

• La Salvia, Anna
• Carletti, Raffaella
• Verrico, Monica
• Feola, Tiziana
• Puliani, Giulia
• Bassi, Massimiliano
• Sesti, Franz
• Pernazza, Angelina
• Mazzilli, Rossella
• Lamberti, Giuseppe
• Siciliani, Alessandra
• Mancini, Massimiliano
• Manai, Chiara
• Venuta, Federico
• Ibrahim, Mohsen
• Tomao, Silverio
• D'Amati, Giulia
• Di Gioia, Cira
• Giannetta, Elisa
• Cappuzzo, Federico
• Faggiano, Antongiulio

Titel

Angioside: The role of Angiogenesis and Hypoxia in Lung Neuroendocrine Tumours According to Primary Tumour Location in Left or Right Parenchyma

Ist Teil von

• Journal of clinical medicine, 2022-10, Vol.11 (19), p.5958

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Well-differentiated lung neuroendocrine tumours (Lu-NETs), classified as typical (TC) and atypical (AC) carcinoids, represent 30% of NETs. Angiogenesis plays an essential role in NET development and progression. A higher vascular network is a marker of differentiation, with positive prognostic implications. Materials and Methods: We retrospectively evaluated microvessel density (MVD) by CD34 immunohistochemical (IHC) staining and hypoxia by IHC staining for Hypoxia-inducible factor 1α (HIF-1α), comparing right- and left-lung parenchyma in 53 lung NETs. Results: The median age was 66 years (39−81), 56.6% males, 24.5% AC, 40.5% left-sided tumours and 69.8% TNM stage I. The mitotic count was <2/10 per 10 HPF in 79.2%, and the absence of necrosis in 81.1%, 39.6% with Ki67, was ≤2%. The MVD, the number of vessels and the average vessel area median values were significantly higher in the right than the left parenchyma (p: 0.025, p: 0.019, p: 0.016, respectively). Hypoxia resulted present in 14/19 (73.6%) left tumours and in 10/20 (50%) right tumours in the parenchyma (p: 0.129). Conclusions: This study suggests a biological rationale for a different angiogenesis and hypoxia according to the Lu-NETs’ location. In our study, left primary tumours were less vascularized and most likely to present hypoxia than right primary tumours. This finding could have potentially useful prognostic and predictive implications for Lu-NETs.