Details

Autor(en) / Beteiligte

• Wilmet, Baptiste
• Callebert, Jacques
• Duvoisin, Robert
• Goulet, Ruben
• Tourain, Christophe
• Michiels, Christelle
• Frederiksen, Helen
• Schaeffel, Frank
• Marre, Olivier
• Sahel, José Alain
• Audo, Isabelle
• Picaud, Serge
• Zeitz, Christina

Titel

Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia

Ist Teil von

• International journal of molecular sciences, 2022-12, Vol.24 (1), p.219

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Mutations in are one of the most common causes of autosomal recessive complete congenital stationary night blindness (cCSNB). This retinal disease is characterized in patients by impaired dim and night vision, associated with other ocular symptoms, including high myopia. cCSNB is caused by a complete loss of signal transmission from photoreceptors to ON-bipolar cells. In this study, we hypothesized that the lack of and the subsequent impaired ON-pathway could lead to myopic features in a mouse model of cCSNB. Using ultra performance liquid chromatography, we show that adult mice have a significant decrease in both retinal dopamine and 3,4-dihydroxyphenylacetic acid, compared to mice. This alteration of the dopaminergic system is thought to be correlated with an increased susceptibility to lens-induced myopia but does not affect the natural refractive development. Altogether, our data added a novel myopia model, which could be used to identify therapeutic interventions.