Details

Autor(en) / Beteiligte

• Cao, Xi‐Shan
• Zhao, Wen
• Wen, Xu‐Hui
• Han, Yu‐Ling
• Yan, Li
• Jiang, Ting‐Wang
• Huang, Jin‐Hong
• Chen, Hong
• Zheng, Wen‐Qi
• Hu, Zhi‐De

Titel

Pleural homocysteine for malignant pleural effusion: A prospective and double‐blind diagnostic test accuracy study

Ist Teil von

• Thoracic cancer, 2022-08, Vol.13 (16), p.2355-2361

Ort / Verlag

Melbourne: John Wiley & Sons Australia, Ltd

Erscheinungsjahr

2022

Quelle

Wiley Online Library Journals【Remote access available】

Beschreibungen/Notizen

• Objective To assess the accuracy of pleural fluid homocysteine for discriminating malignant pleural effusion (MPE) and benign pleural effusion (BPE). Methods A total of 194 patients from two cohorts (Hohhot and Changshu) with undiagnosed pleural effusion were prospectively enrolled. Their pleural homocysteine was measured, and its diagnostic accuracy and net benefit for MPE were analyzed by receiver operating characteristic (ROC) curve analysis and decision curve analysis, respectively. Results In the Hohhot cohort (n = 136) and the Changshu cohort (n = 58), MPE patients had significantly higher homocysteine levels than BPE patients. The areas under the ROC curves of homocysteine for the diagnosis of MPE were 0.61 (p = 0.027) and 0.59 (p = 0.247), respectively. The decision curves of homocysteine were close to the reference line in both the Hohhot cohort and the Changshu cohort. Conclusion The diagnostic accuracy of pleural fluid homocysteine for MPE was low. Two previous studies reported that pleural fluid homocysteine is a promising diagnostic marker for malignant pleural effusion. However, the diagnostic accuracy of pleural fluid homocysteine was low in our two cohorts. Possible explanations for the inconsistency, as well as its clinical implications, were discussed.