Details

Autor(en) / Beteiligte

• Biscione, Fernando Martín
• Westin Mateus Rodrigues
• Ribeiro, Karina Mota
• Estevam Denize Lotufo
• Cardoso, Sandra Wagner
• Tenore Simone Barros
• Neto Lauro Ferreira da Silva Pinto
• Alencastro Paulo Ricardo
• Suffert Theodoro Armando
• de Moraes Mônica Jacques
• Barbosa Alexandre Naime
• Morejón Karen Mirna Loro
• de Arruda Érico Antônio Gomes
• Silveira, Jussara María
• Neto José Luiz Andrade
• Greco Dirceu Bartolomeu
• Unaí, Tupinambás

Titel

Virologic and Immunologic Effectiveness at 48 Weeks of Darunavir–Ritonavir-Based Regimens in Treatment-Experienced Persons Living with HIV-1 Infection in Clinical Practice

Ist Teil von

• Journal of the International Association of Providers of AIDS Care, 2014-01, Vol.13 (1), p.63-68

Ort / Verlag

Thousand Oaks: SAGE PUBLICATIONS, INC

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Introduction:Published data addressing the effectiveness of darunavir–ritonavir (DRV/r)-based therapy for multiexperienced patients in developing countries are scarce. This study evaluated the 48-week virologic and immunologic effectiveness of salvage therapy based on DRV/r for the treatment of multidrug-experienced HIV-1-infected adults in Brazil.Materials and Methods:A multicenter retrospective cohort study was carried out with multidrug-experienced adults who were on a failing antiretroviral therapy and started a DRV/r-based salvage therapy between 2008 and 2010. The primary effectiveness end point was the proportion of patients with virologic success (plasma HIV-1 RNA <50 copies/mL at week 48).Results:At 48 weeks, 73% of the patients had HIV-RNA <50 copies/mL and a mean increase of 108 CD4 cells/mm3. Higher baseline viral load, lower baseline CD4 count, younger age, and 3 or more DRV/r-associated resistance mutations were significantly predictive of virologic failure. Concomitant use of raltegravir was strongly associated with virologic success.Conclusion:The use of DRV/r-based regimens for salvage therapy is an effective strategy in the clinical care setting of a developing country.