Molecules (Basel, Switzerland), 2021-03, Vol.26 (6), p.1591
2021
Details
- Autor(en) / Beteiligte
- Titel
- Recent Advances and Trends in Chemical CPP-Drug Conjugation Techniques
- Ist Teil von
- Molecules (Basel, Switzerland), 2021-03, Vol.26 (6), p.1591
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)-drug conjugates targeting cancer cells. We will focus on small organic molecules as well as metal complexes that were used as cytostatic payloads. Moreover, two principle ways of coupling chemistry will be discussed direct conjugation as well as the use of bifunctional linkers. While direct conjugation of the drug to the CPP is still popular, the use of bifunctional linkers seems to gain increasing attention as it offers more advantages related to the linker chemistry. Thus, three main categories of linkers will be highlighted, forming either disulfide acid-sensitive or stimuli-sensitive bonds. All techniques will be thoroughly discussed by their pros and cons with the aim to help the reader in the choice of the optimal conjugation technique that might be used for the synthesis of a given CPP-drug conjugate.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules26061591Titel-ID: cdi_doaj_primary_oai_doaj_org_article_497aed6745e34ef3a8c5976bc8ec0885
- Format
- –
- Schlagworte
- Amino Acid Sequence, Amino acids, Animals, anticancer drugs, Biocompatibility, bioconjugation, Breast cancer, Cell Line, Tumor, cell-penetrating peptides, Cell-Penetrating Peptides - administration & dosage, Cell-Penetrating Peptides - chemical synthesis, Chemistry, Conjugates, Conjugation, Coordination compounds, Coupling (molecular), Cytostatic Agents - administration & dosage, Cytostatic Agents - chemical synthesis, Cytostatic Agents - chemistry, Deoxyribonucleic acid, Dihydrofolate reductase, DNA, Drug Carriers - administration & dosage, Drug Carriers - chemical synthesis, Drug Carriers - chemistry, Drug Delivery Systems - methods, Drug Delivery Systems - trends, Drugs, Efficiency, Humans, Metal complexes, Molecular Structure, Nanoparticles, Organic chemistry, Organic Chemistry Phenomena, Payloads, peptide synthesis, Peptides, peptide–drug conjugates, Proteins, Review, Synthesis, Trends