Journal of biomedical science, 2017-09, Vol.24 (1), p.76-76, Article 76
2017
Details
- Autor(en) / Beteiligte
- Titel
- Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation
- Ist Teil von
- Journal of biomedical science, 2017-09, Vol.24 (1), p.76-76, Article 76
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, RNA, protein and lipid products that can be used as possible disease progression markers. Although the oxidative stress has been anticipated as a main cause in promoting both AD and T2DM, multiple pathways could be involved in ROS production. The focus of this review is to summarize the mechanisms involved in ROS production and their possible association with AD and T2DM pathogenesis and progression. We have also highlighted the role of current treatments that can be linked with reduced oxidative stress and damage in AD and T2DM.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1423-0127, 1021-7770eISSN: 1423-0127DOI: 10.1186/s12929-017-0379-zTitel-ID: cdi_doaj_primary_oai_doaj_org_article_482a5c4afe504f1fb67bf1c578d4a811
- Format
- –
- Schlagworte
- Aging, Alzheimer Disease - etiology, Alzheimer Disease - physiopathology, Alzheimer Disease - prevention & control, Alzheimer's disease, Anti-diabetic drugs, Antidiabetics, Antioxidant treatments, Apoptosis, Chemicals, Damage, Deoxyribonucleic acid, Diabetes, Diabetes mellitus, Diabetes Mellitus, Type 2 - etiology, Diabetes Mellitus, Type 2 - physiopathology, Diabetes Mellitus, Type 2 - prevention & control, DNA, Enzymes, Health aspects, Humans, Insulin, Lipids, Metabolism, Metals, Neurodegenerative diseases, Neurosciences, Organisms, Oxidation, Oxidative Stress, Pathogenesis, Physiological aspects, Physiology, Proteins, Reactive Nitrogen Species - metabolism, Reactive oxygen species, Reactive Oxygen Species - metabolism, Review, Ribonucleic acid, RNA, Rodents, ROS production, Toxicity, Type-2 diabetes mellitus