Details

Autor(en) / Beteiligte

• Borges, Katia Regina Assunção
• Wolff, Lais Araújo Souza
• da Silva, Marcos Antonio Custódio Neto
• de Carvalho Silva, Allysson Kayron
• Campos, Carmem Duarte Lima
• Souza, Franscristhiany Silva
• Teles, Amanda Mara
• Vale, André Álvares Marques
• Pascoa, Henrique
• Lima, Eliana Martins
• de Sousa, Eduardo Martins
• Nunes, Ana Clara Silva
• Gil da Costa, Rui M
• Faustino-Rocha, Ana Isabel
• Cardoso Carvalho, Rafael
• Nascimento, Maria do Desterro Soares Brandão

Titel

Açaí ( Euterpe oleracea Mart. ) Seed Oil and Its Nanoemulsion: Chemical Characterisation, Toxicity Evaluation, Antioxidant and Anticancer Activities

Ist Teil von

• Current issues in molecular biology, 2024-05, Vol.46 (5), p.3763-3793

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography-mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.