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Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection
Ist Teil von
Toxins, 2021-12, Vol.13 (12), p.880
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2021
Quelle
MEDLINE
Beschreibungen/Notizen
is an opportunistic, Gram-negative pathogen and an important cause of hospital acquired infections, especially in immunocompromised patients. Highly virulent
strains use a type III secretion system (T3SS) to inject exoenzyme effectors directly into the cytoplasm of a target host cell.
strains that express the T3SS effector, ExoU, associate with adverse outcomes in critically ill patients with pneumonia, owing to the ability of ExoU to rapidly damage host cell membranes and subvert the innate immune response to infection. Herein, we review the structure, function, regulation, and virulence characteristics of the T3SS effector ExoU, a highly cytotoxic phospholipase A
enzyme.