Nutrients, 2022-11, Vol.14 (23), p.5074
2022
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- Autor(en) / Beteiligte
- Titel
- The Metabolic Role of Ketogenic Diets in Treating Epilepsy
- Ist Teil von
- Nutrients, 2022-11, Vol.14 (23), p.5074
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu14235074Titel-ID: cdi_doaj_primary_oai_doaj_org_article_47570b703bbd42eba5e1dfc3709a407b
- Format
- –
- Schlagworte
- Adenosine, Age, Alternative energy, biomarkers, Brain research, Convulsions & seizures, Defibrillators, Diet, Diet, Ketogenic - methods, Drug resistance, Drug Resistant Epilepsy, Epilepsy, Fatty acids, High fat diet, Humans, Ketogenesis, ketogenic diet, Ketone Bodies, Ketones, Low carbohydrate diet, Medical imaging, Medical research, Medicine, Experimental, Metabolic disorders, Metabolism, Neuroimaging, Neurophysiology, Neuroprotection, parameters, Patients, Pediatrics, Pharmacokinetics, Review, Seizures, Seizures (Medicine), Surgery, Treatment Outcome