Details

Autor(en) / Beteiligte

• Petrikkos, Loizos
• Kourti, Maria
• Antoniadi, Kondylia
• Tziola, Tatiana-Sultana
• Sfetsiori, Angeliki-Eleni
• Antari, Vasiliki
• Savoukidou, Sofia
• Avgerinou, Georgia
• Filippidou, Maria
• Papakonstantinou, Eugenia
• Polychronopoulou, Sophia
• Hatzipantelis, Emmanuel
• Doganis, Dimitrios
• Kattamis, Antonios
• Papadakis, Vassilios
• Roilides, Emmanuel
• Tragiannidis, Athanasios

Titel

Central Nervous System Fungal Diseases in Children with Malignancies: A 16-Year Study from the Infection Working Group of the Hellenic Society of Pediatric Hematology Oncology

Ist Teil von

• Journal of fungi (Basel), 2024-09, Vol.10 (9), p.654

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• We analyzed data on pediatric invasive fungal diseases of the central nervous system (CNS-IFDs) reported by five of a total of eight Pediatric Hematology-Oncology Departments in Greece for 16 years (2007-2022). A total of twelve patients (11 boys, median age: 9.5 years, range: 2-16) were reported suffering from CNS-IFDs. The underlying malignancy was acute lymphoblastic leukemia in 9/12 and acute myeloid leukemia, Ewing sarcoma, and rhabdomyosarcoma in one each. Eleven patients presented with CNS-related symptoms (i.e., seizures, headache, cerebral palsy, ataxia, hallucination, seizures, blurred vision, amaurosis). All patients had pathological MRI findings. Multifocal fungal disease was observed in 6/12 patients. Nine proven and three probable CNS-IFD cases were diagnosed. Causative pathogens in proven cases were spp. and (n = 2 each), spp., , spp., and (n = 1 each). Causative pathogens in probable cases were spp. (n = 2) and spp. (n = 1). All patients received appropriate antifungal therapy (median duration: 69.5 days, range 19-364). Two patients underwent additional surgical treatment. Six patients were admitted to the Intensive Care Unit due to complications. Three patients (25%) died, two due to IFD and one due to an underlying disease. Early recognition and prompt intervention of CNS-IFDs may rescue the patients and improve overall survival.