Journal of hematology and oncology, 2019-04, Vol.12 (1), p.43-43, Article 43
2019
Details
- Autor(en) / Beteiligte
- Titel
- Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand
- Ist Teil von
- Journal of hematology and oncology, 2019-04, Vol.12 (1), p.43-43, Article 43
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- The ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase 1 (CHK1) pathway plays an essential role in suppressing replication stress from DNA damage and oncogene activation. Preclinical studies have shown that cancer cells with defective DNA repair mechanisms or cell cycle checkpoints may be particularly sensitive to ATR inhibitors. Preclinical and clinical data from early-phase trials on three ATR inhibitors (M6620, AZD6738, and BAY1895344), either as monotherapy or in combination, were reviewed. Data from ATR inhibitor-based combinational trials might lead to future expansion of this therapy to homologous recombination repair pathway-proficient cancers and potentially serve as a rescue therapy for patients who have progressed through poly ADP-ribose polymerase inhibitors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1756-8722eISSN: 1756-8722DOI: 10.1186/s13045-019-0733-6Titel-ID: cdi_doaj_primary_oai_doaj_org_article_4713a58947ee46baab9adcbdc9096b91
- Format
- –
- Schlagworte
- Antineoplastic agents, Apoptosis, Ataxia, Ataxia telangiectasia, Ataxia Telangiectasia - genetics, Ataxia Telangiectasia - pathology, Ataxia Telangiectasia Mutated Proteins - genetics, ATR, ATR inhibitors, Biomarkers, Biotechnology, Cancer, Cancer cells, Cancer genetics, Cancer research, Cancer therapies, Cancer treatment, Carboplatin, Cell cycle, Cell Line, Tumor, Checkpoint Kinase 1 - genetics, Chemotherapy, CHK1 protein, Clinical trials, Cyclin-dependent kinases, Deoxyribonucleic acid, Development and progression, DNA, DNA biosynthesis, DNA damage, DNA Damage - genetics, DNA repair, Genetic aspects, Genetic research, Hematology, Homologous recombination, Homologous recombination repair, Humans, Ionizing radiation, Kinases, Lung cancer, Lymphoma, Monosaccharides, Mutation, Oncology, Ovarian cancer, Phosphorylation, Physiological aspects, Proteins, Replication stress, Review, Ribose, Stress response, Telangiectasis, Tumors