Details

Autor(en) / Beteiligte

• Gimeno Brias, Silvia
• Stack, Gabrielle
• Stacey, Maria A
• Redwood, Alec J
• Humphreys, Ian R

Titel

The Role of IL-22 in Viral Infections: Paradigms and Paradoxes

Ist Teil von

• Frontiers in immunology, 2016-05, Vol.7, p.211-211

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2016

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.