Details

Autor(en) / Beteiligte

• Liu, Xue
• Jin, Zengguang
• Summers, Stephanie
• Derous, Davina
• Li, Min
• Li, Baoguo
• Li, Li
• Speakman, John R.

Titel

Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression

Ist Teil von

• Cell reports (Cambridge), 2022-05, Vol.39 (7), p.110835-110835, Article 110835

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Caloric restriction is a robust intervention to increase lifespan. Giving less food (calorie restriction [CR]) or allowing free access to a diluted diet with indigestible components (calorie dilution [CD]) are two methods to impose restriction. CD does not generate the same lifespan effect as CR. We compare responses of C57BL/6 mice with equivalent levels of CR and CD. The two groups have different responses in fat loss, circulating hormones, and metabolic rate. CR mice are hungrier, as assessed by behavioral assays. Although gene expression of Npy, Agrp, and Pomc do not differ between CR and CD groups, CR mice had a distinctive hypothalamic gene-expression profile with many genes related to starvation upregulated relative to CD. While both result in lower calorie intake, CR and CD are not equivalent procedures. Increased hunger under CR supports the hypothesis that hunger signaling is a key process mediating the benefits of CR. [Display omitted] •CD causes greater loss of fat mass than CR•CR mice have greater food anticipatory behavior compared with CD mice•CR leads to greater reduction in energy expenditure and higher RER than CD•Hypothalamic gene expression is consistent with more hunger after CR than CD Liu et al. compare the impacts of calorie restriction (CR) and calorie dilution (CD) on morphology, metabolism, behavior, and hypothalamic gene expression. Increased hunger under CR suggests that hunger signaling is a key process involved in mediating the benefits of CR for lifespan. CR and CD are not equivalent procedures.