Details

Autor(en) / Beteiligte

• MOORTHY, Vasee S
• HUTUBESSY, Raymond
• NEWMAN, Robert D
• HOMBACH, Joachim

Titel

Decision-making on malaria vaccine introduction: the role of cost―effectiveness analyses

Ist Teil von

• Bulletin of the World Health Organization, 2012-11, Vol.90 (11), p.864-866

Ort / Verlag

Genève: Organisation mondiale de la santé

Erscheinungsjahr

2012

Quelle

PAIS Index

Beschreibungen/Notizen

• Policy-makers in countries where malaria is endemic are facing increasingly complex decisions about which vaccines and malaria prevention measures to include in national immunization and malaria control programmes. Several new vaccines and malaria preventive measures are already competing for limited financing in developing countries. African countries with endemic malaria should be ready to make a national policy decision on the introduction of RTS,S/AS01, a first-generation malaria vaccine, by 2015. If clinical trials progress according to schedule, that same year the World Health Organization will issue a policy recommendation on the public health use of this vaccine based on the findings of the full Phase III efficacy trial in progress, which will be available in late 2014. Cost-effectiveness is an important consideration in public health decision-making. This article summarizes critical parameters driving malaria vaccine cost-effectiveness predictions and discusses major uncertainties that remain in the cost-effectiveness modelling arena. It also highlights the need for ongoing work by modelling groups to further refine cost-effectiveness predictions.