Details

Autor(en) / Beteiligte

• Chi, Hoang Thanh
• Ly, Bui Thi Kim
• Vu, Hoang Anh
• Sato, Yuko
• Dung, Phu Chi
• Xinh, Phan Thi

Titel

Down-regulated expression of NPM1 in IMS-M2 cell line by(-)-epigallocatechin-3-gallate

Ist Teil von

• Asian Pacific journal of tropical biomedicine, 2014-07, Vol.4 (7), p.570-574

Ort / Verlag

China: Elsevier B.V

Erscheinungsjahr

2014

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Objective:To investigate the inhibited effect of epigallocatechin-3-gallate(EGCG)on the expression of NPM1 in IMS-M2 cells harboring the NPMl mutations.Methods:Cell proliferation assay was performed to test the effects of EGCG on eell growth of IMS-M2 cells harboring the NPM1 mutations.Western blot analysis were performed to test the protein expression of NPM1,AKT,those associated with apoplosis.Results:EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the NPM1mutations.Moreover,EGCG also suppressed the cell proliferation and induced apoptosis in IMSM2 cells.Conclusions:The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.