Nature communications, 2021-05, Vol.12 (1), p.2936-2936, Article 2936
2021
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- Autor(en) / Beteiligte
- Titel
- Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
- Ist Teil von
- Nature communications, 2021-05, Vol.12 (1), p.2936-2936, Article 2936
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav sensory neurons, which are involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice. The ablation of Nav -expressing sensory neurons is associated with extensive skin lesions characterized by enhanced inflammatory cytokine and chemokine production. Mechanistically, Nav sensory neurons are required for the downregulation of neutrophil infiltration in the skin after viral clearance to limit the severity of tissue damage and restore skin homeostasis, as well as for eliciting robust CD8 T cell priming in skin-draining lymph nodes by controlling dendritic cell responses. Collectively, our data reveal an important role for the sensory nervous system in regulating both innate and adaptive immune responses to viral infection, thereby opening up possibilities for new therapeutic strategies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-021-22841-6Titel-ID: cdi_doaj_primary_oai_doaj_org_article_42a3ec0604df491d8f51a1b9be9121c7
- Format
- –
- Schlagworte
- Ablation, Adaptive immunity, Animal models, Animals, Blistering, Blisters, CD8 antigen, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - metabolism, CD8-Positive T-Lymphocytes - virology, Chemokines, Cytokines, Cytokines - immunology, Cytokines - metabolism, Dendritic cells, Female, Herpes simplex, Herpes Simplex - genetics, Herpes Simplex - immunology, Herpes Simplex - virology, Herpes viruses, Herpesvirus 1, Human - immunology, Herpesvirus 1, Human - physiology, Homeostasis, Humans, Immune clearance, Immune response, Immune system, Infections, Inflammation, Leukocytes (neutrophilic), Life Sciences, Lymph nodes, Lymphocytes, Lymphocytes T, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, NAV1.8 Voltage-Gated Sodium Channel - genetics, NAV1.8 Voltage-Gated Sodium Channel - immunology, NAV1.8 Voltage-Gated Sodium Channel - metabolism, Nervous system, Neurons, Neutrophil Infiltration - immunology, Nociceptive Pain - genetics, Nociceptive Pain - immunology, Nociceptive Pain - metabolism, Pain, Pain perception, Priming, Robustness, Sensory neurons, Sensory Receptor Cells - immunology, Sensory Receptor Cells - metabolism, Sensory Receptor Cells - virology, Skin - immunology, Skin - metabolism, Skin - virology, Skin diseases, Skin lesions, Sodium channels (voltage-gated), Viral infections, Viruses