Details

Autor(en) / Beteiligte

• Montagnese, Concetta
• Porciello, Giuseppe
• Vitale, Sara
• Palumbo, Elvira
• Crispo, Anna
• Grimaldi, Maria
• Calabrese, Ilaria
• Pica, Rosa
• Prete, Melania
• Falzone, Luca
• Libra, Massimo
• Cubisino, Serena
• Poletto, Luigina
• Martinuzzo, Valentina
• Coluccia, Sergio
• Esindi, Nadia
• Nocerino, Flavia
• Minopoli, Anita
• Grilli, Bruna
• Fiorillo, Pasqualina C
• Cuomo, Marco
• Cavalcanti, Ernesta
• Thomas, Guglielmo
• Cianniello, Daniela
• Pinto, Monica
• De Laurentiis, Michelino
• Pacilio, Carmen
• Rinaldo, Massimo
• D'Aiuto, Massimiliano
• Serraino, Diego
• Massarut, Samuele
• Caggiari, Laura
• Evangelista, Chiara
• Steffan, Agostino
• Catalano, Francesca
• Banna, Giuseppe L
• Scandurra, Giuseppa
• Ferraù, Francesco
• Rossello, Rosalba
• Antonelli, Giovanna
• Guerra, Gennaro
• Farina, Amalia
• Messina, Francesco
• Riccardi, Gabriele
• Gatti, Davide
• Jenkins, David J A
• Celentano, Egidio
• Botti, Gerardo
• Augustin, Livia S A

Titel

Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Ist Teil von

• Nutrients, 2020-12, Vol.13 (1), p.136

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status ( < 0.001), physical ( = 0.003), role ( = 0.002) and social functioning ( < 0.001), body image ( < 0.001), future perspective ( < 0.001), well-being ( = 0.001), and reductions in fatigue ( < 0.001), nausea and vomiting ( = 0.015), dyspnea ( = 0.001), constipation ( = 0.049), financial problems ( = 0.012), sexual functioning ( = 0.025), systematic therapy side effects ( < 0.001) and breast symptoms ( = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status ( = 0.048) and between serum 25(OH)D levels and breast symptoms ( = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.