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Abstract
Background and objective
Breast cancer remains the most common cause of cancer mortality in women. The aim of this study was to investigate associations between genetic variability in
GSTM1
and
GSTT1
and susceptibility to breast cancer.
Methods
Genomic DNA was extracted from blood samples for 80 cases of histologically diagnosed breast cancer and 100 control subjects. Genotyping analyses were performed by PCR-based methods. Associations between specific genotypes and the development of breast cancer were examined using logistic regression to calculate odds ratios [1] and 95% confidence intervals (95%CI).
Results
No correlation was found between
GSTM1
-
null
and breast cancer (OR = 1.83; 95%CI 0.90-3.71; p = 0.10), while
GSTT1
-
null
(OR = 2.42; 95%CI 1.17-5.02; p= 0.01) was associated with increased breast cancer risk. The
GSTM1
/
GSTT1 double null
was not associated with an increased risk of developing breast cancer (OR = 2.52; 95%CI 0.75-8.45
; p
=
0.20)
. Furthermore, analysis found no association between
GSTM1
-
null
(OR =1.12; 95%CI 0.08-15.50;
p
=
1.00
) or
GSTT1
-
null
(OR = 1.71; 95%CI 0.13-22.51;
p
=
1.00
) and the disease stage of familial breast cancer patients or sporadic breast cancer patients (
GSTM1
(OR = 0.40; 95%CI 0.12-1.32;
p = 0.20
) and
GSTT1
(OR = 1.41; 95%CI 0.39-5.12;
p
=
0.75
)). Also, body mass index (BMI) was not associated with increased or decreased breast cancer risk in either GSTM1-null (OR = 0.60; 95%CI 0.21-1.68;
p
=
0.44)
or GSTT1-null (OR = 0.60; 95%CI 0.21-1.68;
p
=0.45).
Conclusion
Our results suggest that only
GSTT1-null
is associated with increased susceptibility to breast cancer development.