Details

Autor(en) / Beteiligte

• Sheikh-Ahmad, Mohammad
• Saiegh, Leonard
• Shalata, Anan
• Bejar, Jacob
• Kreizman-Shefer, Hila
• Sirhan, Majd F
• Matter, Ibrahim
• Swaid, Forat
• Laniado, Monica
• Mubariki, Nama
• Rainis, Tova
• Rosenblatt, Ilana
• Yovanovich, Ekaterina
• Agbarya, Abed

Titel

Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study

Ist Teil von

• Biomedicines, 2023-03, Vol.11 (3), p.828

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11-288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21-67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.