Details

Autor(en) / Beteiligte

• Peluso, Michael J
• Deveau, Tyler-Marie
• Munter, Sadie E
• Ryder, Dylan
• Buck, Amanda
• Beck-Engeser, Gabriele
• Chan, Fay
• Lu, Scott
• Goldberg, Sarah A
• Hoh, Rebecca
• Tai, Viva
• Torres, Leonel
• Iyer, Nikita S
• Deswal, Monika
• Ngo, Lynn H
• Buitrago, Melissa
• Rodriguez, Antonio
• Chen, Jessica Y
• Yee, Brandon C
• Chenna, Ahmed
• Winslow, John W
• Petropoulos, Christos J
• Deitchman, Amelia N
• Hellmuth, Joanna
• Spinelli, Matthew A
• Durstenfeld, Matthew S
• Hsue, Priscilla Y
• Kelly, J Daniel
• Martin, Jeffrey N
• Deeks, Steven G
• Hunt, Peter W
• Henrich, Timothy J

Titel

Chronic viral coinfections differentially affect the likelihood of developing long COVID

Ist Teil von

• The Journal of clinical investigation, 2023-02, Vol.133 (3), p.1-11

Ort / Verlag

United States: American Society for Clinical Investigation

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• BACKGROUNDThe presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a longer time course consistent with current case definitions of LC are limited.METHODSIn a cohort of 280 adults with prior SARS-CoV-2 infection, we assessed the presence and types of LC symptoms and prior medical history (including COVID-19 history and HIV status) and performed serological testing for EBV and CMV using a commercial laboratory. We used covariate-adjusted binary logistic regression models to identify independent associations between variables and LC symptoms.RESULTSWe observed that LC symptoms, such as fatigue and neurocognitive dysfunction, at a median of 4 months following initial diagnosis were independently associated with serological evidence suggesting recent EBV reactivation (early antigen-diffuse IgG positivity) or high nuclear antigen (EBNA) IgG levels but not with ongoing EBV viremia. Serological evidence suggesting recent EBV reactivation (early antigen-diffuse IgG positivity) was most strongly associated with fatigue (OR = 2.12). Underlying HIV infection was also independently associated with neurocognitive LC (OR = 2.5). Interestingly, participants who had serologic evidence of prior CMV infection were less likely to develop neurocognitive LC (OR = 0.52).CONCLUSIONOverall, these findings suggest differential effects of chronic viral coinfections on the likelihood of developing LC and association with distinct syndromic patterns. Further assessment during the acute phase of COVID-19 is warranted.TRIAL REGISTRATIONLong-term Impact of Infection with Novel Coronavirus; ClinicalTrials.gov NCT04362150.FUNDINGThis work was supported by NIH/National Institute of Allergy and Infectious Diseases grants (3R01AI141003-03S1, R01AI158013, and K24AI145806); the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, Infectious Diseases, and Global Medicine; and the UCSF-Bay Area Center for AIDS Research (P30-AI027763).