Nature communications, 2022-10, Vol.13 (1), p.6436-12, Article 6436
2022
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Details
- Autor(en) / Beteiligte
- Titel
- The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
- Ist Teil von
- Nature communications, 2022-10, Vol.13 (1), p.6436-12, Article 6436
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic HIV infection causes persistent low-grade inflammation that induces premature aging of the immune system including senescence of memory and effector CD8 T cells. To uncover the reasons of gradually diminished potency of CD8 T cells from people living with HIV, here we expose the T cells to planar lipid bilayers containing ligands for T-cell receptor and a T-cell integrins and analyze the cellular morphology, dynamics of synaptic interface formation and patterns of the cellular degranulation. We find a large fraction of phenotypically naive T cells from chronically infected people are capable to form mature synapse with focused degranulation, a signature of a differentiated T cells. Further, differentiation of aberrant naive T cells may lead to the development of anomalous effector T cells undermining their capacity to control HIV and other pathogens that could be contained otherwise.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-022-34157-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_407d31e3a7eb459ca34825405bc8e052
- Format
- –
- Schlagworte
- Aging, CD8 antigen, CD8-Positive T-Lymphocytes, Cell Differentiation, Chronic infection, Cytology, Degranulation, Effector cells, HIV, HIV Infections, Human immunodeficiency virus, Humans, Immune system, Immunological memory, Immunological synapses, Immunology, Infections, Integrins, Lipid bilayers, Lipids, Lymphocyte Count, Lymphocytes, Lymphocytes T, Medicin och hälsovetenskap, Memory cells, Senescence, Synapses, Synaptogenesis, T cell receptors