Details

Autor(en) / Beteiligte

• Wilson, Kerrie
• Case, Marian
• Minto, Lynne
• Bailey, Simon
• Bown, Nick
• Jesson, Jenny
• Lawson, Sarah
• Vormoor, Josef
• Irving, Julie

Titel

Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia

Ist Teil von

• Haematologica (Roma), 2010-04, Vol.95 (4), p.679-683

Ort / Verlag

Italy: Ferrata Storti Foundation

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Flow cytometric minimal residual disease (MRD) monitoring could become more powerful if directed towards the disease-maintaining leukemic stem cell (LSC) compartment. Using a cohort of 48 children with B-lineage acute lymphoblastic leukemia (ALL), we sought the newly proposed candidate-LSC population, CD34(+)CD38(low)CD19(+), at presentation and in end of induction bone marrow samples. We identified the candidate LSC population in 60% of diagnostic samples and its presence correlated with expression of CD38, relative to that of normal B-cell progenitors. In addition, the candidate LSC was not detectable in all MRD positive samples. The absence of the population in 40% of diagnostic and 40% of MRD positive samples does not support the use of this phenotype as a generic biomarker to track LSCs and suggests that this phenotype may be an artifact of CD38 underexpression rather than a biologically distinct LSC population. ClinicalTrials.gov Identifier: NCT00222612.