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For researchers and journal editors, AI-based systems will enable more complex problems to be addressed, based on input from multiple sources of information, an approach that is not possible or would be impossibly slow without assistance from AI. The first period (from 1879 to 2004) was dominated by Index Medicus and essentially involved having to go to the library to look for a precise reference in the large Index books, finding the relevant issue of the journal (if stocked) on the library shelf, and then making a ‘xerox copy.’ The post-publication impact of articles and spread of information will also be facilitated, by automatic identification of the important novel aspects of published research, leading to more rapid application of effective new concepts and/or meaningful improvements in practice.