Details

Autor(en) / Beteiligte

• Montes-Cobos, Elena
• Bastos, Victoria C.
• Monteiro, Clarice
• de Freitas, João C.R.
• Fernandes, Heiny D.P.
• Constancio, Clarice S.
• Rodrigues, Danielle A.S.
• Gama, Andreza M.D.S.
• Vidal, Vinicius M.
• Alves, Leticia S.
• Zalcberg-Renault, Laura
• de Lira, Guilherme S.
• Ota, Victor A.
• Caloba, Carolina
• Conde, Luciana
• Leitão, Isabela C.
• Tanuri, Amilcar
• Ferreira, Orlando D.C.
• Pereira, Renata M.
• Vale, André M.
• Castiñeiras, Terezinha M.
• Kaiserlian, Dominique
• Echevarria-Lima, Juliana
• Bozza, Marcelo T.

Titel

Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-spike antibodies

Ist Teil von

• iScience, 2023-07, Vol.26 (7), p.107219-107219, Article 107219

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The vast spectrum of clinical features of COVID-19 keeps challenging scientists and clinicians. Low resistance to infection might result in long-term viral persistence, but the underlying mechanisms remain unclear. Here, we studied the immune response of immunocompetent COVID-19 patients with prolonged SARS-CoV-2 infection by immunophenotyping, cytokine and serological analysis. Despite viral loads and symptoms comparable to regular mildly symptomatic patients, long-term carriers displayed weaker systemic IFN-I responses and fewer circulating pDCs and NK cells at disease onset. Type 1 cytokines remained low, while type-3 cytokines were in turn enhanced. Of interest, we observed no defects in antigen-specific cytotoxic T cell responses, and circulating antibodies displayed higher affinity against different variants of SARS-CoV-2 Spike protein in these patients. The identification of distinct immune responses in long-term carriers adds up to our understanding of essential host protective mechanisms to ensure tissue damage control despite prolonged viral infection. [Display omitted] •Immunocompetent oligosymptomatic COVID-19 patients may have persistent infection•Long-term COVID-19 patients show low antiviral immunity, with fewer NK cells/pDCs•A systemic type 3 immune profile characterizes persistent SARS-CoV-2 infection•Long-term carriers develop anti-spike antibodies with enhanced binding capacity Health sciences; Immunology; Virology