Cell & bioscience, 2021-07, Vol.11 (1), p.1-131, Article 131
2021
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- Autor(en) / Beteiligte
- Titel
- Pathological alterations in the gastrointestinal tract of a porcine model of DMD
- Ist Teil von
- Cell & bioscience, 2021-07, Vol.11 (1), p.1-131, Article 131
- Ort / Verlag
- London: BioMed Central Ltd
- Erscheinungsjahr
- 2021
- Quelle
- SpringerLink (Online service)
- Beschreibungen/Notizen
- Here we employed the CRISPR/Cas9 system combined with somatic nuclear transfer technology (SCNT) to establish a porcine model of DMD and explored their pathological alterations. We found that genetic disruption of dystrophin expression led to morphological gastrointestinal tract alterations, weakened the gastrointestinal tract digestion and absorption capacity, and eventually led to malnutrition and gastric dysfunction in the DMD pigs. This work provides important insights into the pathogenesis of DMD and highlights the need to consider the gastrointestinal dysfunction as an additional therapeutic target for DMD patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2045-3701eISSN: 2045-3701DOI: 10.1186/s13578-021-00647-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_3f290dbccec54069b4285143eb13cf9e
- Format
- –
- Schlagworte
- Analysis, Animal models, Apoptosis, Autophagy, Cardiac muscle, Cardiomyopathy, CRISPR, Dehydrogenases, Duchenne muscular dystrophy, Duchenne's muscular dystrophy, Dystrophin, Gastrointestinal diseases, Gastrointestinal system, Gastrointestinal tract, Gene expression, Genome editing, Genomics, Health aspects, Hogs, Kinases, Malnutrition, Muscles, Muscular dystrophy, Musculoskeletal system, Mutation, Nuclear transfer, Pig, Porcine, Proteins, Skeletal muscle, Smooth muscle, Swine, Therapeutic targets, Utrophin