International journal of molecular sciences, 2023-04, Vol.24 (9), p.7892
2023
Details
- Autor(en) / Beteiligte
- Titel
- Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors
- Ist Teil von
- International journal of molecular sciences, 2023-04, Vol.24 (9), p.7892
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2023
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Multidrug-resistant Gram-negative bacteria such as , , and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring the urgent discovery and development of therapeutic strategies. We present here an overview of the antibiotic resistance profiles and epidemiology of Gram-negative pathogens listed in the ESCAPE group circulating in Romania. The review starts with a discussion of the mechanisms and clinical significance of Gram-negative bacteria, the most frequent genetic determinants of resistance, and then summarizes and discusses the epidemiological studies reported for , , and Enterobacterales-resistant strains circulating in Romania, both in hospital and veterinary settings and mirrored in the aquatic environment. The Romanian landscape of Gram-negative pathogens included in the ESCAPE list reveals that all significant, clinically relevant, globally spread antibiotic resistance genes and carrying platforms are well established in different geographical areas of Romania and have already been disseminated beyond clinical settings.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms24097892Titel-ID: cdi_doaj_primary_oai_doaj_org_article_3edd25ae407d4164ada09c5b75781a7e
- Format
- –
- Schlagworte
- Acinetobacter baumannii, Acinetobacter baumannii - genetics, Anti-Bacterial Agents - pharmacology, Antibiotic resistance, Antibiotics, Antimicrobial agents, Antimicrobial resistance, Aquatic ecological zones, Aquatic environment, aquatic resistome, Bacteria, Cell division, Cloxacillin, community-acquired, Drug resistance, Drug resistance in microorganisms, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial - genetics, Enterobacterales, Enzymes, Epidemiology, Gram-negative bacteria, Gram-Negative Bacteria - genetics, Gram-negative ESCAPE pathogens, Health aspects, Imipenem, intra-hospital infections, Microbial Sensitivity Tests, Multidrug resistance, Mutation, Pathogenic microorganisms, Pathogens, Proteins, Pseudomonas aeruginosa, Public health, resistance, Review, Romania - epidemiology, Sulbactam, Tazobactam, Tetracycline, Tetracyclines