Details

Autor(en) / Beteiligte

• Macneil, Adam
• Ströher, Ute
• Farnon, Eileen
• Campbell, Shelley
• Cannon, Deborah
• Paddock, Christopher D
• Drew, Clifton P
• Kuehnert, Matthew
• Knust, Barbara
• Gruenenfelder, Robert
• Zaki, Sherif R
• Rollin, Pierre E
• Nichol, Stuart T

Titel

Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011

Ist Teil von

• Emerging infectious diseases, 2012-08, Vol.18 (8), p.1256-1262

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.